Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary TargetCOX-1

Product does not compete with ATP.

ED50 = 15 µM against COX-1

General description

A phenolic product found in both grape skins and wines. Has antifungal, antitumor, and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED₅₀ = 15 µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED₅₀ = 3.7 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED₅₀ = 27 µM) and acts as an anti-mutagenic agent (ED₅₀ = 15 µM) in TM677 cells treated with DMBA. Also a selective inhibitor of P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.

A phenolic product found in both grape skin and wines. Has anti-fungal, anti-tumor and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED₅₀ = 15 µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED₅₀ = 3.7 µM). Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED₅₀ = 27 µM) and acts as an anti-mutagenic agent (ED₅₀ = 15 µM) in TM677 cells treated with DMBA. Also selectively inhibits P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Howitz, K.T., et al. 2003. Nature425, 191.Lin, H.Y., et al. 2002. J. Urol.168, 748.Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312.Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun.262, 20.Jang, M., et al. 1997. Science 275, 218.Chen, C.K., et al. 1996. Gen. Pharmacol.27, 363.

Packaging

25 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)