General description

A cell-permeable, thiazolidinedione (TZD) that acts as an inhibitor of MitoNEET (IC₅₀ = 0.9 µM) in competition with rosiglitazone and pioglitazone, in liver mitochondrial suspensions. In pharmacological studies, it was found to alter isolated mitochondrial complex I respiration with an IC₅₀ of 2.4 µM and inhibited State III respiration up to 45%. Furthermore, this compound (6-25 µM) is shown to dose-dependently reduce lactate-dehydrogenase release in SH-SY5Y cultures, leading to a 40% decrease in rotenone-induced cell-death.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Geldenhuys, W.J., et al. 2009. Bioorg Med Chem Lett.3, 819.Giles, R.G., et al. 2000. Tetrahedron56, 4531.

Packaging

10 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)