Biochem/physiol Actions

Cell permeable: no

Target IC₅₀: 10-15 nM, 0.1 nM against protein phosphatase 1, protein phosphatase 2A, respectively

Reversible: no

Product does not compete with ATP.

General description

Water-soluble analog of Okadaic Acid (Cat. No. 495604). Inhibits protein phosphatases 1 and 2A.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Gjertsen, B.T., et al. 1994. J. Cell Sci.107, 3363.Kiguchi, K., et al. 1994. Cell Growth Differentiation5, 995.Ohaka, Y., et al. 1993. Biochem. Biophys. Res. Commun.197, 916.Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun.189, 950.Kreienbuhl, P., et al. 1992. Blood80, 2911.Normura, M., et al. 1992. Biochemistry31, 11915.Song, Q., et al. 1992. J. Cell Physiol.153, 550.Tada, Y., et al. 1992. Immunopharmacol.24, 17.Cohen, P., et al. 1990. Trends Biochem. Sci.15, 98.Cohen, P. 1989. Annu. Rev. Biochem.58, 453.Cohen, P., and Cohen, P.T.W. 1989. J. Biol. Chem.254 21435.Haystead, T.A. et al. 1989. Nature337, 78.

Packaging

25 µg in Alu drum

Warning

Toxicity: Toxic (F)