Application

Triphosgene can be employed as a reagent to prepare: Thiocarbonates from thiols and alcohols by one-pot, three-component reaction.Substituted azetidin-2-ones from acids and imines via ketene–imine cycloaddition reaction. Methyl (S)-2-isocyanato-3-phenylpropanoate from L-phenylalanine methyl ester hydrochloride in the presence of sodium bicarbonate. Acyl azides derivatives from various carboxylic acids and sodium azide. Immunosuppressant agent cyclosporin by solid-phase peptide synthesis.Allyl azides from allyl alcohols and sodium azide in one pot method.Esterification coupling reagent di-2-thienyl carbonate, from 2(5H)-thiophenone.2-Chloronicotinaldehydes via cyclization of the corresponding enamides.

General description

Triphosgene [Bis(trichloromethyl)carbonate] is a versatile organic reagent used in organic synthesis alternative to phosgene. A catalytic amount of triphosgene is particularly used in chloroformylations, carbonylations, chlorinations, and dehydration reactions.

Packaging

5, 25, 100, 500 g in glass bottle