CaMKII Inhibitor XII

Code: 208923-5MG D2-231

General description

A pyrimidinyl sulfonamide compound that acts as a potent, reversible and CaM non-competitive inhibitor of CaMKII activities (IC50 = 0.063 µ...


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£177.00 EACH
£212.40 inc. VAT

General description

A pyrimidinyl sulfonamide compound that acts as a potent, reversible and CaM non-competitive inhibitor of CaMKII activities (IC50 = 0.063 µM) with excellent selectivity over several kinases (IC50 = >60, 36, 11, 30 and 21 µM for CaMKIV, MLCK, p38α, Akt1 and PKC, respectively). Shown to exhibit ~25-fold greater potency towards CaMKII than the CaM-competitive inhibitor KN-93 (Cat. No. 422708).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Asano, S., et al. 2010. Bioorg. Med. Chem. Lett.20, 6696.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)

assay≥99% (HPLC)
colorwhite
formpowder
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inwet ice
solubilityDMSO: 100 mg/mL
storage conditionprotect from light, OK to freeze
storage temp.2-8°C
Cas Number1208123-85-6
This product has met the following criteria: