Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary Targetprotein kinase G

Cell permeable: yes

General description

Cell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP. Preferentially activates protein kinase G. Inhibits thrombin-stimulated arachidonic acid release in human platelets.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Kwak, B.R., and Jongsma, H.J. 1996. Mol. Cell. Biochem. 157, 93.Perreault, T., and DeMarte, J. 1993. Am. J. Physiol. 264, H302.Ruth, P., et al. 1991. Eur. J. Biochem.202, 1339.Schwarzschild, M.A., and Zigmond, R.E. 1991. J. Neurochem.56, 400.

Packaging

Packaged under inert gas

25 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 week at -20°C.

Warning

Toxicity: Standard Handling (A)