Biochem/physiol Actions
Reversible: no
Product does not compete with ATP.
Cell permeable: yes
Primary TargetPKA
General description
Cell-permeable cAMP analog that has greater resistance to phosphodiesterases than cAMP. Preferentially activates protein kinase A (PKA). Directly activates Epac, a Rap1 guanine-nucleotide exchange factor.
Cell-permeable cAMP analog that is more resistant to phosphodiesterases than cAMP. Preferentially activates cAMP-dependent protein kinase (PKA). Induces the guanine-nucleotide-exchange factor activity of GEFI, also known as Epac (exchange protein directly activated by cAMP), and GEFII toward Rap1 both in vivo and in vitro.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Kawasaki, H., et al. 1998. Science 282, 2275.de Rooij, J., et al. 1998. Nature 396, 474.Boyer, B., and Thiery, J.P. 1993. J. Cell Biol.120, 767.Hei, Y.-J., et al. 1991. Mol. Pharmacol. 39, 233.
Packaging
10 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid pH >8.5.
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria: