Biochem/physiol Actions

Primary TargetNeurotoxin that binds to Na+ channels on nerves and muscles.

Cell permeable: no

Reversible: no

Product does not compete with ATP.

General description

Lipid-soluble polyether neurotoxin that binds to Na⁺ channels on nerves and muscles causing an excessive influx of Na⁺ across membranes. Binds at site 5 on the voltage-sensitive Na⁺ channel.

Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na⁺ channel activator that causes contractile paralysis in animal models. The excitatory action on nerve and muscle membranes is responsible for a wide spectrum of toxic effects, including massive transmitter release from nerve endings, muscle fasiculation, and ventricular fibrillation. The excitatory action is due to opening of the Na⁺ channels. The toxin does not bind either to the TTX or to the aconitine/veratridine sites.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Edwards, R.A., et al. 1992. Mol. Brain Res.14, 64.Trainer, V.L. 1991. Mol. Pharmacol.40, 988.Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol.103, 1126.Trainer, V.L., et al. 1990. ACS Symposium Series418, 166.Baden, G. 1989. FASEB J.3, 1807.Baden, D.G., et al. 1988. Toxicon26, 97.Poli, M.A., et al. 1986. Mol. Pharmacol.30, 129.Shimizu, Y., et al. 1986. J. Am. Chem. Soc.108, 514.Nakanishi, K. 1985. Toxicon23, 473.Baden, D.G., et al. 1982. Toxicon19, 455.Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol.19, 345.

Packaging

Packaged under inert gas

100 µg in Glass bottle

yes

Reconstitution

Following reconstitution, aliquot, purge with iniert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.r>r>r>From Catalog:r>Solubitlity- removed acetone, EtOAc

Warning

Toxicity: Highly Toxic (H)