Biochem/physiol Actions

Primary TargetNegative control compound for protein kinase C inhibition

Reversible: no

Product does not compete with ATP.

Target IC₅₀: >100 µM as negative control compound for protein kinase C inhibition; 8 µM in blocking the activation of mitogen-stimulated protein kinase p70s6k/p85s6k in vivo

Cell permeable: yes

General description

A cell-permeable negative control compound for protein kinase C inhibition studies (IC₅₀ >100 µM). Blocks the activation of p70^s6k/p85^s6kin vivo (IC₅₀ = 8 µM).

A cell-permeable negative control compound for protein kinase C inhibition studies (IC₅₀ >100 µM). Blocks the activation of mitogen-stimulated protein kinase p70^s6k/p85^s6kin vivo (IC₅₀ 8 µM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Marmy-Conus, N., et al. 2002. FEBS Lett. 26094 (In Press) 1-6.Davis, P.D., et al. 1992. J. Med. Chem.35, 177.Toullec, D., et al. 1991. J. Biol. Chem.266, 15771.

Packaging

1 mg in Plastic ampoule

400 µg in Plastic ampoule

Warning

Toxicity: Standard Handling (A)