Application

Convenient form of anhydrous HF, stable up to 50°C. Has been used for the preparation of β-fluoroamines from amino alcohols and for the fluorination of acetylenes.Used together with hypervalent iodine(III) reagents for ipso-fluorination of para-substituted phenols providing cyclohexadienones. Employed with Selectfluor^™ (Catalog No. 439479) for geminal fluorination of 2,2-diaryl-1,3-dithiolanes.

Reactant for preparation of:•Epimers of shikimic acid with the features of fucosylated glycans via zinc-mediated reductive ring opening followed by a Barbier reaction•Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure•Candidates for nucleic acid drugs•ω-substituted gem-difluoroalkanes by oxidative desulfurization-difluorinationReagent for:•Halofluorination reactions

General description

May contain or form low levels of calcium fluoride during storage. Presence of this does not impact the specification values.

Legal Information

Selectfluor is a registered trademark of Merck KGaA, Darmstadt, Germany

Sure/Pac is a trademark of Sigma-Aldrich Co. LLC

Packaging

25, 100 g in poly bottle