Application

New, Safer, NIMBA-Stabilized BH3 THF Solutions

BH₃-THF can be used as a reducing agent for the reduction of various functional groups such as carboxylic acids, aldehydes, ketones, esters, acid chlorides, nitriles, epoxides, amides, lactones, oximes, and imines into corresponding alcohols and amines. Grignard reagents, arylmercury, arylthalium, and allyl and propargyllithium compounds react with BH₃−THF to give organoboranes, which can be oxidized to the corresponding alcohols, phenols, and 1,3-diols.It can also be used: To synthesize the chiral borane catalyst, which is used in the enantioselective halo-aldol reaction.To prepare 9-unsubstituted acridines by reduction of corresponding acridones.To reduce nylon surface amide groups to secondary amines.

General description

Borane tetrahydrofuran complex (BH₃-THF) is widely used as a reducing agent in organic synthesis. It is also used as a reagent in hydroboration reactions.

Legal Information

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Packaging

4×25, 100, 800 mL in Sure/Seal™

The 25 mL Sure/Seal^™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.