Biochem/physiol Actions

Primary TargetAPP

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Target IC₅₀: 30 nM against amyloid precursor protein (APP) β-secretase

General description

A potent inhibitor of the amyloid precursor protein (APP) β-secretase (IC₅₀ = 30 nM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Sinha, S., et al. 1999. Nature 402, 537.

Packaging

500 µg in Plastic ampoule

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Stat-Val-Ala-Glu-Phe-OH [Stat = (3S,4S)-Statine]

Warning

Toxicity: Standard Handling (A)