Application

Analogue of the BOP coupling reagent which does not form carcinogenic HMPA as by-product.

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) may be used in the following studies:As coupling reagent in the preparation strategies for peptide-oligonucleotide conjugates.Synthesis of structured pure triacylglycerol (TAG) regioisomers. As coupling reagent in the synthesis of a 3,5-pyrazolidinedione on soluble polyethylene glycol (PEG) polymer support.Synthesis of herceptin- nanoparticles.

General description

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification. It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.

Legal Information

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany