UG NF-kB SN50; CELL-PERM. INHIBITOR PEPT

Code: 481480-500UG D2-231

Biochem/physiol Actions

Product does not compete with ATP.

Primary Targettranslocation of the NF-κB active complex into the nucleus

Cell permeable: yes


read more

Your Price
£229.00 EACH
£274.80 inc. VAT

Biochem/physiol Actions

Product does not compete with ATP.

Primary Targettranslocation of the NF-κB active complex into the nucleus

Cell permeable: yes

General description

Contains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-κB nuclear translocation is maximally inhibited at 18 µM.

Contains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The peptide N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, inhibition of NF-κB nuclear translocation is maximally inhibited at 18 µM.

NF-κB SN50, CAS 213546-43-3, is a cell-permeable peptide that contains the NLS sequence of NF-κB p50 linked to the hydrophobic region of K-FGF. Inhibits translocation of the NF-κB into the nucleus.

Legal Information

Sold under license of U.S. Patents 5,807,746 and 6,043,339 for research use only. Licenses for commercial manufacture, commercial use, diagnostics, or therapeutics may be obtained by contacting Vanderbilt University, Nashville, Tennessee.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.

Packaging

1 mg in Plastic ampoule

500 µg in Plastic ampoule

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.

Sequence

H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH

Warning

Toxicity: Standard Handling (A)

assay≥97% (HPLC)
formlyophilized
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inambient
solubilitywater: 5 mg/mL
storage conditiondesiccated (hygroscopic), OK to freeze
storage temp.−20°C
Code
Description
Unit Size
List Price
Qty
481480-1MG
Unit:1MG
List Price: £325.00
Source:List Price
ADD
This product has met the following criteria: