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The epitope recognized by PLA0290 maps to a region between residue 526 and 576 of human Coilin using the numbering given in entry NP_004636.1 (GeneID 8161).
Coilin is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6PJP8].
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide