Biochem/physiol Actions

PCK1 (phosphoenolpyruvate carboxykinase 1) participates in gluconeogenesis, glyceroneogenesis and cataplerosis. It transforms oxaloacetic acid (OAA) into phosphoenol pyruvate (PEP) with the help of guanosine triphosphate (GTP). PEPCK is linked with type 2 diabetes.

General description

PCK1 (phosphoenolpyruvate carboxykinase 1) is an enzyme that is expressed in humans as two isoforms- cytosolic PEPCK (cPEPCK) and mitochondrial PEPCK (mPEPCK). PCK1 gene is located on human chromosome 20q13.

Immunogen

PCK1 (AAH23978, 1 a.a. ~ 622 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceMPPQLQNGLNLSAKVVQGSLDSLPQAVREFLENNAELCQPDHIHICDGSEEENGRLLGQMEEEGILRRLKKYDNCWLALTDPRDVARIESKTVIVTQEQRDTVPIPKTGLSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLSKIGIELTDSPYVVASMRIMTRMGTPVLEALGDGEFVKCLHSVGCPLPLQKPLVNNWPCNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRMASRLAKEEGWLAEHMLVLGITNPEGEKKYLAAAFPSACGKTNLAMMNPSLPGWKVECVGDDIAWMKFDAQGHLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLASGVTITSWKNKEWSSEDGEPCAHPNSRFCTPASQCPIIDAAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKIIMHDPFAMRPFFGYNFGKYLAHWLSMAQHPAAKLPKIFHVNWFRKDKEGKFLWPGFGENSRVLEWMFNRIDGKASTKLTPIGYIPKEDALNLKGLGHINMMELFSISKEFWEKEVEDIEKYLEDQVNADLPCEIEREILALKQRISQM

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Physical form

Solution in phosphate buffered saline, pH 7.4