Leucine is a non-glucogenic, essential amino acid. It is a branched-chain amino acid that is a structural component of proteins. Leucine positively influences insulin release to eliminate toxic sugars out of the blood. The degradation of leucine leads to the formation of ketone bodies.
L-Leucine has been used as an agonist of mechanistic target of rapamycin (mTOR) to determine whether AMPK/mTOR pathway is involved in berberine-mediated autophagy in J774A.1 cells. It has also been used for the selection of transformed cells.
- Synonym: (S)-2-Amino-4-methylpentanoic acid
- CAS Number: 61-90-5
- Linear Formula: (CH3)2CHCH2CH(NH2)CO2H
- Molecular Weight: 131.17
- Beilstein Registry Number: 1721722
- EC Number: 200-522-0
- MDL Number: MFCD00002617
- eCl@ss: 32160406
- PubChem Substance ID: 24896488
- Grade: Reagent grade
- InChI Key: ROHFNLRQFUQHCH-YFKPBYRVSA-N
- Assay: ≥98% (HPLC)
- Impurities: Isoleucine and methionine, essentially free
- mp: >300 °C (lit.)