Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Target IC₅₀: 53 nM against glycogen phosphorylase

Cell permeable: yes

Primary TargetGlycogen phosphorylase

General description

A cell-permeable urea compound that acts as a potent and AMP-competitive inhibitor of glycogen phosphorylase (GP; IC₅₀ = 53 nM). Shown to inhibit glucagon-induced glyocgenolysis both in hepatocytes (IC₅₀ = 380 nM) in vitro and in rats (5 mg/kg, iv) in vivo.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Klabunde, T., et al. 2005. J. Med. Chem.48, 6178

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Irritant (B)