General description

Calponin is a 34-kD polypeptide that interacts with actin, tropomyosin, and calmodulin. Itis involved in the smooth muscle contraction mechanism and is restricted exclusively to smoothmuscle tissue. Anti-calponin has been found to be useful in staining myoepithelium and thushas been used to confirm the presence of myoepithelial cells in benign breast proliferationand their absence in invasive breast carcinomas. Calponin positivity has also been noted inmyoepithelial neoplasms and pleomorphic adenoma of the salivary gland.

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

Calponin Positive Control Slides, Product No. 231S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

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Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide

Preparation Note

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Quality