Biochem/physiol Actions

tRNA methyltransferase 6 (TRMT6), also known as GCD10 (General control non-derepressible protein 10), is essential for initiating protein synthesis. TRMT6 encoded polypeptide is required for cell viability and consists of a sequence related to the RNA-recognition motif, which is found in many RNA-binding proteins. It helps in DNA methylation. Mutations in TRMT6 along with other genes might be linked to tumorigenesis. It acts as a translational repressor of (general control protein) GCN4.

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General description

tRNA methyltransferase 6 (TRMT6), also known as GCD10 (General control non-derepressible protein 10), is a 54.6 kDa protein. The gene is located on human chromosome 20p12.3.

Immunogen

Synthetic peptide directed towards the middle region of human TRMT6

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Sequence

Synthetic peptide located within the following region: GAMMERMGGFGSIIQLYPGGGPVRAATACFGFPKSFLSGLYEFPLNKVDS