SAB2501623-100UG Display Image

Anti-SFRP1 (C-terminal) antibody produced in goat, affinity isolated antibody, buffered aqueous solution

Code: SAB2501623-100UG D2-231

Biochem/physiol Actions

Secreted Frizzled-related protein 1 (SFRP1) is a secreted inhibitor of Wnt signaling pathway. DNA damage or oxidative stress causes cellular senescenc...

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£457.00 100UG
List Price

Biochem/physiol Actions

Secreted Frizzled-related protein 1 (SFRP1) is a secreted inhibitor of Wnt signaling pathway. DNA damage or oxidative stress causes cellular senescence, which leads to the overexpression of sfrp1. This protein induces senescence phenotypes via the inactivation of Wnt signaling and activation of the retinoblastoma (Rb) pathway. Mutations or aberrant methylation in this gene impair the induction of senescence in several cancers, including breast cancer, bladder cancer, and colorectal tumorigenesis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

The gene SFRP1 (secreted frizzled related protein 1) is mapped to human chromosome 8p22–p12, a region frequently deleted in breast cancer. It is highly expressed in normal breast tissue.

Immunogen

Peptide with sequence KNHECPTFQSVFK, from the C-terminal region of the protein sequence according to NP_003003.3

Physical form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

clonepolyclonal
antibody formaffinity isolated antibody
Gene Informationhuman ... SFRP1(6422)
shipped indry ice
biological sourcegoat
application(s)indirect ELISA: suitable
application(s)immunohistochemistry: suitable
storage temp.−20°C
Quality Level100
antibody product typeprimary antibodies
conjugateunconjugated
UniProt accession no.Q8N474
species reactivitybovine, human, mouse
formbuffered aqueous solution