Application

Anti-Cyclic Nucleotide-Gated Cation Channel A3 (CNGA3) antibody produced in rabbit is suitable for western blotting at a dilution of 1:200 using rat brain membranes.

Biochem/physiol Actions

Cyclic nucleotide-gated cation channel alpha-3 is a protein encoded by the CNGA3 gene in humans. It is also referred as CNG3, ACHM2, CCNC1, CCNCa, CNCG3 and CCNCalpha. A cyclic nucleotide-gated (CNG) channel serves as essential target for sensory transduction in retinal photoreceptors and olfactory receptor cells. CNGA3 subunits specify the arrangement of subunits containing L633P and other mutations which leads to interact between channel subunits or intersubunit. Its mutations are the most common cause of cone-rod dystrophies and achromatopsia.

Immunogen

synthetic peptide corresponding to amino acids 594-611 of rat CNGA3. Mouse is 15/18 residues identical.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, 1% BSA, and 0.05% sodium azide.

Specificity

Also recognizes the two published isoforms of CNGA3.