SAB2501384-100UG Display Image

Anti-CSF1R antibody produced in goat, affinity isolated antibody, buffered aqueous solution

Code: SAB2501384-100UG D2-231

Biochem/physiol Actions

CSF1R (colony stimulating factor 1 receptor), and its ligand CSF1 are linked to poor prognosis in patients with solid tumors, and in patients with fem...

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£457.00 100UG
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Biochem/physiol Actions

CSF1R (colony stimulating factor 1 receptor), and its ligand CSF1 are linked to poor prognosis in patients with solid tumors, and in patients with female reproductive cancers. In breast cancers, with decreased claudin levels, this protein regulates the switch between proliferative and invasive state of the tumor, acting downstream of TGFß (tumor growth factor ß). Haploinsufficiency in this receptor might lead to aberration of microglial function, which might be a contributor to the pathogenesis of hereditary diffuse leukoencephalopathy with spheroids (HDLS).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

CSF1R (colony stimulating factor 1 receptor) or FMS, acts as a receptor for CSF1, and regulates monocyte and macrophage functioning. It is a member of the platelet-derived growth factor (PDGF) family of proteins, and is a type III RTK (receptor tyrosine kinase). CSF1R is composed of five immunoglobulin (Ig)-like domains, a transmembrane region, a juxtamembrane domain and kinase insert domain (KID) intersecting the kinase domain.

Immunogen

Peptide with sequence KNIHLEKKYVR, from the internal region of the protein sequence according to NP_005202.2

Physical form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

application(s)western blot: suitable
application(s)indirect ELISA: suitable
clonepolyclonal
antibody formaffinity isolated antibody
species reactivitymouse, canine, rat, human
shipped indry ice
biological sourcegoat
Gene Informationhuman ... CSF1R(1436)
storage temp.−20°C
Quality Level100
antibody product typeprimary antibodies
UniProt accession no.P07333
conjugateunconjugated
formbuffered aqueous solution