BIRC6 is a member of a family of proteins that inhibit apoptosis, likely through interference with activation of ICE-like proteases. BIRC6, which contains a single BIR domain and a ubiquitin-conjugating enzyme domain, is expressed in four of six brain cancers (gliomas), and one of five ovarian cancers in a variety of human cancer cell lines. Brain cancer cell lines that overexpress BIRC6 demonstrate multi-drug resistance BIRC6 may protect cancer cells from undergoing apoptosis and participate in tumorigenesis and drug resistance.
BIRC6 (BIR6_HUMAN, 27-62)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human BIRC6.
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.